According to the law of Bergonie and Tribondeau, which factor increases cell radiosensitivity?

The law of Bergonie and Tribondeau states that the sensitivity of cells to radiation is influenced by several factors, primarily the age of the cells, their level of differentiation, and their metabolic activity. According to this law, cells that are more actively dividing (high proliferation), less differentiated (immature), and exhibit a high metabolic rate are more radiosensitive.

When considering why the third choice is valid, increased proliferation is directly associated with a higher likelihood of being affected by radiation. Cells that are in the process of division are more vulnerable during certain phases of the cell cycle, particularly during mitosis. Additionally, immature cells, which are less differentiated, are still developing and have not yet acquired the specialized functions of mature cells; this makes them more susceptible to radiation damage. A high metabolic rate also correlates with increased activity within the cell and a greater demand for energy and resources, which can lead to enhanced radiosensitivity.

In contrast, the other options include characteristics that tend to reduce radiosensitivity. For example, increased age, high differentiation, and a mature cell status correspond to more stable and resilient cellular structures, reducing their likelihood of sustaining damage from radiation exposure. Thus, the correct response aligns with the principles of the law of Bergonie and Tribonde